skin science

A New Era in Anti-Aging: Say Goodbye to Traditional Anti-Aging Treatments and Hello to Collagen Modulation

For years, skincare and aesthetic treatments have focused on one thing: boosting collagen to fight signs of aging. While collagen is important for smooth, youthful skin, just increasing it isn’t always enough. Now, experts are taking a smarter approach—modulating collagen for better, longer-lasting results.

YOU MIGHT ALSO LIKE

2025 - 10 - 23

SHARE

For years, skincare and aesthetic treatments have focused on one thing: boosting collagen to fight signs of aging. While collagen is important for smooth, youthful skin, just increasing it isn’t always enough. Now, experts are taking a smarter approach—modulating collagen for better, longer-lasting results.

What is collagen modulation, we hear you ask? And more importantly, what does this mean for your skincare routine?  

Understanding collagen: the key ingredient for youthful skin

Collagen is the most common protein in your body and is found in many places including your skin, bones, tendons, and ligaments. In your skin, collagen is responsible for providing structure and helps it stay smooth, firm and youthful-looking.

There are 16 types of collagen in your body, so it may seem logical to target all of these for youthful skin. Whilst this sounds like a great idea, about 90% of the collagen in your body is type I and approximately 5% is type II and type III. The remaining types of collagen are found in very small amounts, less than 1% each.

Unfortunately, our collagen is not endless. As we age, our ability to replace our natural collagen declines by approximately 1%-1.5% each year.1 Other factors can also speed up the decline of our collagen, for example, sun exposure, smoking and diet. This all contributes to increased signs of aging like fine lines, sagging, and volume loss.

It’s understandable then that the beauty industry discovered the power of collagen and set out to boost it. However, this is only one part of the picture. Let us explain why. 

What is collagen modulation?

Imagine a bucket with a hole in the bottom. You can fill the bucket, but it won’t stay full for long.

The hole in the bucket is your natural collagen being broken down. Stimulating or replacing collagen is filling the bucket, but without addressing collagen degradation, you can’t preserve your collagen for very long.

Here is where collagen modulation plugs the leak in the bucket. 

Through combatting collagen breakdown, you can boost your collagen for longer, slowing down signs of aging such as fine lines, sagging, and volume loss.

By creating a supportive environment for collagen to thrive, you can take advantage of this natural anti-aging protein for radiant, youthful-looking skin.  

Why is collagen modulation the future of skincare?

Collagen modulation isn't just a trend. It’s part of a greater movement in aesthetics. Here’s why it’s gaining popularity:

1. Get straight to the source

As we know, collagen is the key protein in your skin that provides structure. It’s responsible for your skin looking smooth, firm and youthful-looking, so why target anything else? By modulating collagen, you get right to the source, addressing the cause of skin aging

2. The rise of prejuvenation

Prejuvenation is a proactive approach to skin health. This means skincare and aesthetic treatments are being adopted earlier, to prevent signs of aging and maintain skin health. This supports collagen modulation, as our skin’s ability to produce collagen reduces as we age.1 Starting proactive skincare early gives a greater chance to preserve collagen. Prevention is better than cure!

3. Holistic skincare

Holistic skincare is a philosophy that prioritises whole-body wellness, recognising the importance of sleep, nutrition, mental health and so much more. With a focus on natural solutions, holistic skincare partners well with collagen modulation, which harnesses and preserves your natural collagen to work in harmony with your body

How to future proof your skin with collagen modulation

If you’re looking for a complete anti-aging treatment that works with your natural collagen, you’ve come to the right place.

With over 10 years of research distilled into each bottle, the Definisse [KP1]® range was designed with collagen modulation at its core. Researched at the University of Florence, our exclusive, first-in-class, bio-active peptide,2 Key Peptide 1 [KP1, works to protect your collagen from degradation,3-6 preserving your natural collagen for radiant, younger-looking skin. Revolutionise your at-home skincare routine with our simple 3 step Definisse [KP1]® range.

In our words, you can’t stop time, but you can slow it down and make it beautiful. 

References

1. Reilly DM, Penezini F, Errante F, Rovero P, Pascarella S. Skin collagen through the lifestages: importance for skin health and beauty. Plast Aesthet Res. 2021;8:2.

2. Definisse [KP1]® regenerating serum. Florence (Italy): RELIFE Menarini Group.

3. Cipriani C, Rovero P, Errante F, Pascarella S. Serpin A1 and the modulation of type I collagen turnover: effect of the C-terminal peptide 409-418 (SA1-III) in human dermal fibroblasts. Cell Biol Int. 2018;42(3):318–26.

4. Errante F, Rovero P, Pascarella S, Cipriani C. Cosmeceutical peptides in the framework of sustainable wellness economy. Front Chem. 2020;8:572923.

5. Pascarella S, Rovero P, Errante F, Cipriani C. Serpin A1 C-terminal peptides as collagen turnover modulators. ChemMedChem. 2016;11(11):1850–5.

6. Rovero P, Errante F, Pascarella S, Cipriani C. The clinical evidence-based paradigm of topical anti-aging skincare formulations enriched with bio-active peptide SA1-III (KP1) as collagen modulator: from bench to bedside. Clin Cosmet Investig Dermatol. 2022;15:2693–703.