Beautify time. Protect and enhance your skin with our game changing Definisse [KP1]® Collagen Modulator Bio-Peptide
You can't stop time but you can make it beautiful.
We rely on collagen for so much of our skin’s health and appearance, it is a vital component of youthful, supple skin.
Environmental factors such as free radicals and our own biology (certain enzymes) deplete the collagen we naturally produce. Moreover, as we age the skin's ability to produce collagen naturally decreases every year by about 1.0-1.5%.
Many treatments focus on stimulating collagen production - but now you can also protect and maintain the collagen that’s already present.
Introducing the Definisse™ [KP1]® Collagen Modulator Bio-Peptide. Formulated with the exclusive Key Peptide 1 [KP1]®, this skincare range is redefining age prevention by preventing collagen degradation
Combining Key Peptide 1 [KP1]® with high and low molecular hyaluronic acid and other specific ingredients, it delivers improved skin density, firmness, brightness and reduces wrinkles.
Definisse [KP1]® Key Peptide 1 is a collagen modulator that works to inhibit the functioning of the enzymes responsible for depleting collagen.
It helps to increase your collagen levels by protecting what you naturally produce and may even increase production when used in conjunction with minimally invasive aesthetic treatments.
By preventing the degradation of collagen, Definisse ™ [KP1]® Collagen Modulator Bio-Peptide has been clinically proven to increase Collagen Type 1 density in the structural fibres of human skin.1
The Definisse™ [KP1]® Collagen Modulator Bio-Peptide range of creams and serum can reduce all the signs of ageing associated with collagen depletion.
Clinically proven to reduce wrinkles and fine lines, smooth and brighten skin, increase skin density and firmness.
Definisse™ [KP1]® Collagen Modulator Bio-Peptide is an at-home skincare range that is simply massaged into your skin as part of your daily routine.
Apply a small amount to clean skin in the morning and evening by massaging until completely absorbed. Can be used in combination with aesthetic medicine treatments such as fillers and threads to improve results.
This first in class innovation, Definisse™ [KP1]® Collagen Modulator Bio-Peptide, is a skin care range that contains the exclusive key peptide 1 bio-active peptide derived from the Serine Protease Inhibitor Serpin A1. It is the Serpin A1 peptide that inhibits the degradation of collagen.2
Our skin care line also contains skin stimulating vitamins, antioxidants and moisturisers, therefore, not only protecting collagen, but increasing hydration and skin regeneration in one amazing skin care treatment.
And if all of this sounds too good to be true - Definisse™ [KP1]® Collagen Modulator Bio-Peptide has been clinically proven to decrease wrinkles by 10% and increase hydration by 30% in just 4 weeks.2
Take control of your skin with this unique and exclusive collagen preservation skincare programme.
Clinically proven, in collaboration with the University of Florence, as effective in achieving significant improvement on five parameters after only 4 weeks of use: hydration, elasticity, density, roughness, and brightness.
This is made possible by the bio-active functions of the product - proven to increase of the skin density values through an increase or a reorganisation of the dermal structures: collagen fibres, cells and extracellular matrix.3
THE DEFINISSE [KP1]® PRODUCT RANGE
Future proofing
DEFINISSE [KP1]® REGENERATING SERUM
Clinically proven effective in addressing dullness and reducing fine lines and wrinkles.
The highly concentrated, fast-absorbing formula provides immediate and long lasting hydration, promoting a luminous, nourished, and velvety smooth skin.
INGREDIENTS
- White Truffle Extract (fragrance free), that increases skin elasticity and performs
a filling effect
- 2 next-generation HAs, that increase hydration and promote new collagen substrate production
- High molecular weight HA sits on the surface of the skin to prevent dehydration
- Very low molecular weight HA can penetrate deep into the skin to significantly improve hydration
- Vitamin B5 - stimulates the physiological skin regeneration
DEFINISSE [KP1]®REDENSIFYING CREAM
DEFINISSE [KP1]®REDENSIFYING CREAM Clinically proven effective in achieving significant improvement on five parameters The lightweight, easy-to-absorb formula provides immediate and long-lasting hydration, leaving the skin nourished, firm, and velvety smooth.
INGREDIENTS
- Phytosphingosine, that helps to maintain the skin barrier function
- Creatine for cosmetic use, that increases cellular energy
- 2 next-generation HAs, that increase hydration and promote new collagen substrate production
- High molecular weight HA sits on the surface of the skin to prevent dehydration
- Very low molecular weight HA can penetrate deeper into the skin significantly improving hydration
- Vitamin B5, stimulates the physiological skin regeneration
- Vitamin E, with antioxidant properties Avocado oil, that nourishes the skin
- Lactil', a blend of humectants in aqueous solution acting as a substitute of the "Natural Moisturizing Factor" (NMF) of human skin is one bullet point
DEFINISSE [KP1]® REVITALISING EYE CONTOUR
A complete cosmetic treatment for the eye area that reduces wrinkles, dark circles, and under-eye puffiness due to an effective combination of 3 peptides and 3 latest-generation hyaluronic acids.
INGREDIENTS
- Argireline®, a synthetic peptide, that helps inhibit the repetitive contraction of facial expression muscles, thereby reducing hyperkinetic facial lines
- Acetil-tetrapeptide-5, proven effectiveness in reducing dark circles and under eye puffiness
- 3 different types of HA promote new collagen substrate production:
- High molecular weight HA sits on the surface of the skin to prevent dehydration
- Very low molecular weight HA can penetrate deeper into the skin significantly improving hydration
- Cross-linked HA, has a significantly higher ability to hydrate the skin than other HAs, and double the ability to reduce wrinkles and wrinkle
- Vitamin B5, stimulates the physiological skin regeneration
- Vitamin E, with antioxidant properties
- Avocado oil, that nourishes the skin
FAQ
Creatine is a naturally occurring organic compound that works with the body on a cellular level. It can increase cellular energy and therefore support repair, integrity and quality of the skin. Creatine is one of the active ingredients in Definisse [KP1]® redensifying cream.
A collagen modulator regulates and maintains the levels of collagen in the skin. This is made possible by an active ingredient that inhibits the enzymes responsible for degradation of collagen. Definisse [KP1]® Collagen Modulator Bio-Peptide uses the exclusive Serpin A1 peptide to protect the skin’s collagen levels.13
As we age the skin’s ability to replenish collagen naturally decreases by about 1.0 % – 1.5 % per year. This is compounded by environmental and biological factors that can cause degradation of collagen. Definisse™ [KP1]® Collagen Modulator Bio-Peptide skin care range contains the exclusive active ingredient Serpin A1 peptide which inhibits the enzymes in our skin responsible for breaking down our existing collagen, therefore maintaining collagen levels.
COMBINATION TREATMENTS
Definisse [KP1]® Collagen Modulator Bio-Peptide can be combined with other Definisse™ treatments, to achieve the best possible results for optimal wellbeing.
DEFINISSE™ STIMULATE & PROTECT
Combined with a tried & tested favourite brings us an unprecedented treatment - Definisse™ Stimulate & Protect.
Simultaneously enhancing the skin’s ability to both regenerate and prevent erosion of its own collagen, this is dual action advanced protocol.
Definisse™ Revitalise Threads mechanically stimulating collagen creation and the resulting increased firmness. Definisse™ KP1 magnifies the collagen production effect and most significantly protects collagen from degradation by counteracting the enzymes that cause its breakdown. This treatment helps to both preserve and increase the level of collagen in the skin.
References
1. Pascarella S. et al. 2016. Serpin A1 C-terminal peptides as collagen turnover modulators. Chem Med Chem. 11:1850-1855
2. Cipriani C. et al. 2018. Serpin A1 and the modulation of type I collagen turnover: Effect of the C-terminal peptide 409–418 (SA1-III) in human dermal fibroblasts. Cell. Biol. Int. 9999:1-9.
3. Definisse [KP1]® Regenerating Serum. 2022. Instrumental and Subjective Evaluation of the Anti-age Efficacy of a Cosmetic Product. Institute of Skin and Product Evaluation (ISPE s.r.l.). Milan.
July 2025 PP-RL-UK-0904